vi /etc/exim/exim.conf

#MAIN CONFIGURATION
...
system_filter = /etc/exim/filter/exim.filter
system_filter_reply_transport = filter_smtp

#system_filter_directory_transport =
#system_filter_file_transport =
#system_filter_group =
#system_filter_pipe_transport =
#system_filter_reply_transport =
#system_filter_user =
...
...
#TRANSPORTS
begin transports
...
filter_smtp:
  driver = autoreply
...

mkdir /etc/exim/filter/
touch /etc/exim/filter/exim.filter

vi /etc/exim/filter/exim.filter

###MAIL LIST
###if $recipients: contains "mail_list_new@domain.local"
###    then	
###    unseen deliver user1@domain.local
###    unseen deliver user2@domain.local
###    unseen deliver user3@domain.local
###    unseen deliver user4@domain.local
###endif

###AUTOREPLY
###if $recipients: contains "user5@domain.local"
###  then
###       mail from user5@domain.local
###       subject "RE: $h_subject"
###       text "Helo! \n\
###            tel. 123456789"
###endif

###AUTOREPLY
###if $recipients: contains "user6@domain.local"
###	then
###	if $h_from: contains "@domain.local"
###		then
###			mail from user6@domain.local
###			text "Helo! \n\
###               tel. 123456789"
###endif
###endif

###USER NOT EXIST
###if $h_from: contains "user_another@domain.local"
###	then
###		fail text "The user does not exist"
###endif

###CHANGE HEADERS
###if $h_from: contains "@domain.local" and $header_subject: contains "MMM"
###then
###    if $recipients: contains  "@domain2.local"
###    then
###        headers remove From
###        headers remove Sender
###        headers remove Reply-to
###        headers remove Return-path
###        headers remove Envelope-to
###
###        headers add "From: MMM <mmm@domain.local>"
###        headers add "Sender: mmm@domain.local"
###        headers add "Reply-to: mmm@domain.local"
###        headers add "Return-path: mmm@domain.local"
###        headers add "Envelope-to: mmm@domain.local"
###
###        unseen deliver admin@domain.local
###    endif
###endif